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Chemoenzymatic synthesis of chiral 4-(N,N-dimethylamino)pyridine derivatives
dc.contributor.author | Busto García, Benjamín Eduardo | |
dc.contributor.author | Gotor Fernández, Vicente | |
dc.contributor.author | Gotor Santamaría, Vicente Miguel | |
dc.date.accessioned | 2020-05-20T08:06:34Z | |
dc.date.available | 2020-05-20T08:06:34Z | |
dc.date.issued | 2005 | |
dc.identifier.citation | Tetrahedron: Asymmetry, 16(20), p. 3427-3435 (2005); doi:10.1016/j.tetasy.2005.09.006 | |
dc.identifier.issn | 0957-4166 | |
dc.identifier.uri | http://hdl.handle.net/10651/54877 | |
dc.description.abstract | —Chiral 4-(N,N-dimethylamino)pyridine derivatives have been prepared through a chemoenzymatic synthesis where the enzymatic kinetic resolution of a family of 4-chloro-2-(1-hydroxyalkyl)pyridines is the key step for the formation of potentially important chiral catalysts. Pseudomonas cepacia lipase (PSL) showed excellent enantioselectivity in the acylation of the (R)-enantiomers (E > 200) using vinyl acetate as acylating agent and THF as solvent, obtaining products and substrates enantiomerically pure and with excellent yields. | spa |
dc.format.extent | p. 3427-3435 | spa |
dc.language.iso | eng | spa |
dc.relation.ispartof | Tetrahedron: Asymmetry, 16 | spa |
dc.rights | © 2005 Published by Elsevier Ltd. | |
dc.title | Chemoenzymatic synthesis of chiral 4-(N,N-dimethylamino)pyridine derivatives | spa |
dc.type | journal article | spa |
dc.identifier.doi | 10.1016/j.tetasy.2005.09.006 | |
dc.relation.publisherversion | https://doi.org/10.1016/j.tetasy.2005.09.006 | spa |
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