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Lobophorin K, a new natural product with cytotoxic activity produced by Streptomyces sp. M-207 associated with the deep-sea coral Lophelia pertusa

dc.contributor.authorFernández Braña, Alfredo Javier 
dc.contributor.authorSarmiento Vizcaíno, Aida
dc.contributor.authorOsset, Miguel
dc.contributor.authorPérez Victoria, Ignacio
dc.contributor.authorMartín, Jesús
dc.contributor.authorPedro, Nuria de
dc.contributor.authorCruz, Mercedes de la
dc.contributor.authorDíaz, Caridad
dc.contributor.authorVicente, Francisca
dc.contributor.authorReyes, Fernando
dc.contributor.authorGarcía Díaz, Luis Arsenio 
dc.contributor.authorBlanco Blanco, María Gloria 
dc.date.accessioned2018-10-31T11:54:34Z
dc.date.available2018-10-31T11:54:34Z
dc.date.issued2017
dc.identifier.citationMar Drugs, 15(5), p. 1-8 (2017); doi:10.3390/md15050144
dc.identifier.issn1660-3397
dc.identifier.issn1660-3397
dc.identifier.urihttp://hdl.handle.net/10651/49088
dc.description.abstractThe present article describes the isolation of a new natural product of the lobophorin family, designated as lobophorin K (1), from cultures of the marine actinobacteria Streptomyces sp. M-207, previously isolated from the cold-water coral Lophelia pertusa collected at 1800 m depth during an expedition to the submarine Avilés Canyon. Its structure was determined using a combination of spectroscopic techniques, mainly ESI-TOF MS and 1D and 2D NMR. This new natural product displayed cytotoxic activity against two human tumor cell lines, such as pancreatic carcinoma (MiaPaca-2) and breast adenocarcinoma (MCF-7). Lobophorin K also displayed moderate and selective antibiotic activity against pathogenic Gram-positive bacteria such as Staphylococcus aureus.spa
dc.description.sponsorshipThe authors are grateful to José Luis Acuña for his invitation to the BIOCANT3 oceanographic expedition (DOSMARES) where Streptomyces sp. M-207 was isolated. This study was financially supported by the Universidad de Oviedo (UNOV-11-MA-02) and Gobierno del Principado de Asturias (SV-PA-13-ECOEMP-62). The polarimeter, IR, and NMR equipment used in this work were acquired via grants for scientific and technological infrastructures from the Ministerio de Ciencia e Innovación (Grants No. PCT-010000-2010-4 (NMR), INP-2011-0016-PCT-010000 ACT6 (polarimeter and IR)). This is a contribution of the Asturias Marine Observatory.
dc.format.extentp. 1-8spa
dc.language.isoengspa
dc.publisherMDPIspa
dc.relation.ispartofMar Drugs, 15(5)spa
dc.rights© 2017 by the authors. Licensee MDPI, Basel, Switzerland
dc.rightsCC Reconocimiento 4.0 Internacional
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectlobophorinsspa
dc.subjectspirotetronate antibioticspa
dc.subjectStreptomycesspa
dc.subjectantitumorspa
dc.titleLobophorin K, a new natural product with cytotoxic activity produced by Streptomyces sp. M-207 associated with the deep-sea coral Lophelia pertusaspa
dc.typejournal articlespa
dc.relation.projectIDUniversidad de Oviedo/UNOV-11-MA-02
dc.relation.projectIDGobierno del Principado de Asturias/SV-PA-13-ECOEMP-62
dc.relation.projectIDMinisterio de Ciencia e Innovación/PCT-010000-2010-4 (NMR)
dc.relation.projectIDMinisterio de Ciencia e Innovación/INP-2011-0016-PCT-010000 ACT6
dc.relation.publisherversionhttps://doi.org/10.3390/md15050144
dc.rights.accessRightsopen access


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© 2017 by the authors. Licensee MDPI, Basel, Switzerland
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